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Type: article
Title: Diclofenac in hyaluronic acid gel: an alternative treatment for actinic cheilitis
Author(s): Lima, Giana da Silveira
Silva, Gabriela Ferrari da
Gomes, Ana Paula Neutzling
Araújo, Lenita Maria Aver
Salum, Fernanda Gonçalves
Publisher: Bauru School of Dentistry
Issue Date: 2010
Volume: 18
Issue: 5
First page: 533
Last page: 537
Abstract: Objective: Actinic cheilitis (AC) is a precancerous lesion of the lip vermillion caused by prolonged exposure to ultraviolet light. The aim of this study was to evaluate the effect of 3% diclofenac in 2.5% hyaluronic acid gel in the treatment of AC. Methods: Thirty-four patients with chronic AC were treated twice a day with topical diclofenac during a period of 30 to 180 days. The individuals were followed up every 15 days by means of clinical examination and digital photographic documentation. Results: Of the 27 patients that completed the study, 12 (44%) showed complete remission of the whitish plaques and exfoliative areas, and 15 (56%) had partial remission of the clinical picture of cheilitis. The latter group was submitted to excision of the leukoplakic areas which diagnosis varied from mild to moderate epithelial dysplasia. Conclusions: The results suggest a promising role for diclofenac in hyaluronic acid gel in the treatment of AC. This treatment has the advantages of not being invasive and showing few side effects.
DOI: 10.1590/S1678-77572010000500018
PMID: 21085813
ISSN: 1678-7757
Appears in Collections:Artigo de Periódico

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