Please use this identifier to cite or link to this item: http://hdl.handle.net/10923/904
Type: article
Title: Association between bisphosphonates and jaw osteonecrosis: a study in Wistar rats
Author(s): Maahs, Márcia Angélica Peter
Azambuja, Alan Arrieira
Campos, Maria Martha
Salum, Fernanda Gonçalves
Cherubini, Karen
Publisher: Wiley Periodicals, Inc
Issue Date: 2011
Volume: 33
Issue: 2
First page: 199
Last page: 207
Keywords: BISPHOSPHONATES
JAW OSTEONECROSIS
ANGIOGENESIS
ZOLEDRONIC ACID
ALENDRONATE
ODONTOLOGIA
OSSOS - NECROSE
Abstract: BACKGROUND: This work aimed at determining whether bisphosphonate therapy produces a sufficient condition for jaw osteonecrosis after tooth extraction. METHODS: Rats were allocated into 3 groups: (1) 11 rats treated with alendronate, (2) 10 rats treated with zoledronic acid, and (3) 10 control rats. The animals were subjected to tooth extractions, and at the end of bisphosphonate therapy, they were humanely killed. Histologic sections of the surgical site were processed and analyzed. RESULTS: The zoledronic acid group showed higher incidences of osteonecrosis, inflammatory infiltrate, and microorganisms. There was no significant difference for epithelial or connective tissue, root fragments, vital bone, and positive staining for vascular endothelial growth factor (VEGF) among the groups. CONCLUSION: Zoledronic acid is associated with jaw osteonecrosis, whereas alendronate did not produce a condition sufficient for osteonecrosis after tooth extraction. Neither zoledronic acid nor alendronate was associated with a reduced immunohistochemical expression of VEGF in vital bone at the tooth extraction site.
URI: http://hdl.handle.net/10923/904
DOI: 10.1002/hed.21422
PMID: 20848442
ISSN: 1043-3074
Appears in Collections:Artigo de Periódico

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