Please use this identifier to cite or link to this item: http://hdl.handle.net/10923/931
Type: article
Title: Salivary cortisol and dehydroepiandrosterone (dhea) levels, psychological factors in patients with oral lichen planus
Author(s): Girardi, Carla
Luz, Clarice
Cherubini, Karen
Figueiredo, Maria Antonia Zancanaro
Nunes, Maria Lúcia Tiellet
Salum, Fernanda Gonçalves
Publisher: Elsevier
Issue Date: 2011
Volume: 56
Issue: 9
First page: 864
Last page: 868
Keywords: ORAL LICHEN PLANUS
STRESS
ANXIETY
DEPRESSION
DEHYDROEPIANDROSTERONE
CORTISOL
ODONTOLOGIA
LÍQUEN PLANO BUCAL
DEPRESSÃO
ESTOMATOLOGIA CLÍNICA
Abstract: Objective: The aim of this study was to determine the salivary levels of dehydroepiandrosterone (DHEA) and cortisol and scores of depression, anxiety and stress in patients with oral lichen planus (OLP). Study Design: Thirty-one patients with a diagnosis of OLP were selected; they were matched by sex and age with 31 control patients. Symptoms of depression, anxiety and stress were investigated by the instruments Beck Depression Inventory, Beck Anxiety Inventory and Lipp’s Inventory of Stress Symptoms for Adults, respectively. Saliva was collected in the morning and at night for the determination of DHEA and cortisol levels by radioimmunoassay. Results: There was no significant difference between the groups with respect to depression (P=0.832), anxiety (P=0.061) or stress (P=0.611), or with respect to morning and night salivary levels of DHEA (P=0.888, P=0.297) and cortisol (P=0.443, P=0.983). Conclusions: The results suggest an association of OLP with anxiety. However, DHEA and cortisol levels did not differ between groups, which does not support any neuroendocrine aetiology for OLP.
URI: http://hdl.handle.net/10923/931
DOI: 10.1016/j.archoralbio.2011.02.003
PMID: 21377142
ISSN: 0003-9969
Appears in Collections:Artigo de Periódico

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