Utilize este identificador para citar ou criar um atalho para este documento: http://hdl.handle.net/10923/976
Tipo: article
Título: Activity of novel quinoxaline-derived chalcones on in vitro glioma cell proliferation
Autor(es): Mielcke, Tânia R
Mascarello, Alessandra
Filippi-Chiela, Eduardo
Zanin, Rafael F
Lenz, Guido
Leal, Paulo César
Chiaradia, Louise D
Yunes, Rosendo Augusto
Nunes, Ricardo José
Battastini, Ana Maria O
Morrone, Fernanda Bueno
Campos, Maria Martha
Editora: Elsevier
Data de Publicação: 2012
Volume: 48
Página Inicial: 255
Página Final: 264
Palavras-chave: SYNTHESIS
Resumo: Gliomas are the most common and devastating tumors of the central nervous system (CNS). Many pieces of evidence point out the relevance of natural compounds for cancer therapy and prevention, including chalcones. In the present study, eight synthetic quinoxaline-derived chalcones, structurally based on the selective PI3K gamma inhibitor AS605240, were evaluated for anti-proliferative activity and viability inhibition using glioma cell lines from human and rat origin (U-138 MG and C6, respectively), at different time-periods of incubation and concentrations. The results revealed that four chalcones (compounds 1, 6, 7 and 8), which present a methoxy group at A-ring, displayed higher efficacies and potencies, being able to inhibit either cell proliferation or viability, in a time- and concentration-dependent manner, with an efficacy that was greater than that seen for the positive control compound AS605240. Flow cytometry analysis demonstrated that incubation of C6 cells with compound 6 led to G1 phase arrest, likely indicating an interference with apoptosis. Furthermore, compound 6 was able to visibly inhibit AKT activation, allied to the stimulation of ERK MAP-kinase. The chalcones tested herein, especially those displaying a methoxy radical, might well represent promising molecules for the adjuvant treatment of glioma progression.
URI: http://hdl.handle.net/10923/976
DOI: 10.1016/j.ejmech.2011.12.023
PMID: 22209415
ISSN: 0223-5234
Aparece nas Coleções:Artigo de Periódico

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