Campo DC | Valor | Idioma |
dc.contributor.author | Basso, Luiz A | - |
dc.contributor.author | Schneider, Cristopher Z. | - |
dc.contributor.author | Santos, Anderson J. A. B. | - |
dc.contributor.author | Santos-Júnior, André A. | - |
dc.contributor.author | Campos, Maria Martha | - |
dc.contributor.author | Souto, André A. | - |
dc.contributor.author | Santos, Diógenes S. | - |
dc.date.accessioned | 2012-04-26T13:32:13Z | - |
dc.date.available | 2012-04-26T13:32:13Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 0103-5053 | en_US |
dc.identifier.uri | http://hdl.handle.net/10923/914 | - |
dc.description.abstract | Here we describe inhibitory activity of IQG607, pentacyano(isoniazid)ferrate(II), on isoniazid-sensitive and isoniazid-resistant strains of Mycobacterium tuberculosis, oral toxicity, and efforts to adapt IQG607 synthesis to large chemical reactors. IQG607 represents a founding member of a new class of lead compounds aiming at inhibition of a validated and druggable molecular target. | en_US |
dc.description.abstract | Descrevemos a atividade inibitória do IQG607, pentaciano(isoniazida)ferrato(II), frente a
cepas de Mycobacterium tuberculosis tanto resistentes quanto sensíveis à isoniazida, assim como
a toxicidade oral e a adaptação da síntese química do IQG607 para reatores maiores. O IQG607
representa um potencial agente quimioterápico que inibe um alvo molecular definido. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Sociedade Brasileira de Química | en_US |
dc.subject | MYCOBACTERIUM TUBERCULOSIS | en_US |
dc.subject | ENOYL REDUCTASE | en_US |
dc.subject | TOXICOLOGY | en_US |
dc.subject | LARGE-SCALE SYNTHESIS | en_US |
dc.subject | METALLODRUG | en_US |
dc.subject | ODONTOLOGIA | en_US |
dc.subject | TOXICIDADE | en_US |
dc.title | An inorganic complex that inhibits mycobacterium tuberculosis enoyl reductase as a prototype of a new class of chemotherapeutic agents to treat tuberculosis | en_US |
dc.type | article | en_US |
dc.identifier.doi | 10.1590/S0103-50532010000700026 | en_US |
dc.publisher.place | Porto Alegre | pt_BR |
dc.jtitle | Journal of the Brazilian Chemical Society | en_US |
dc.publication.date | 2010 | en_US |
dc.volume | 21 | en_US |
dc.spage | 1384 | en_US |
dc.epage | 1389 | en_US |
Aparece en las colecciones: | Artigo de Periódico
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