Please use this identifier to cite or link to this item:
https://hdl.handle.net/10923/914
Type: | article |
Title: | An inorganic complex that inhibits mycobacterium tuberculosis enoyl reductase as a prototype of a new class of chemotherapeutic agents to treat tuberculosis |
Author(s): | Basso, Luiz A Schneider, Cristopher Z. Santos, Anderson J. A. B. Santos-Júnior, André A. Campos, Maria Martha Souto, André A. Santos, Diógenes S. |
Publisher: | Sociedade Brasileira de Química |
Issue Date: | 2010 |
Volume: | 21 |
First page: | 1384 |
Last page: | 1389 |
Keywords: | MYCOBACTERIUM TUBERCULOSIS ENOYL REDUCTASE TOXICOLOGY LARGE-SCALE SYNTHESIS METALLODRUG ODONTOLOGIA TOXICIDADE |
Abstract: | Here we describe inhibitory activity of IQG607, pentacyano(isoniazid)ferrate(II), on isoniazid-sensitive and isoniazid-resistant strains of Mycobacterium tuberculosis, oral toxicity, and efforts to adapt IQG607 synthesis to large chemical reactors. IQG607 represents a founding member of a new class of lead compounds aiming at inhibition of a validated and druggable molecular target. Descrevemos a atividade inibitória do IQG607, pentaciano(isoniazida)ferrato(II), frente a
cepas de Mycobacterium tuberculosis tanto resistentes quanto sensíveis à isoniazida, assim como
a toxicidade oral e a adaptação da síntese química do IQG607 para reatores maiores. O IQG607
representa um potencial agente quimioterápico que inibe um alvo molecular definido. |
URI: | http://hdl.handle.net/10923/914 |
DOI: | 10.1590/S0103-50532010000700026 |
ISSN: | 0103-5053 |
Appears in Collections: | Artigo de Periódico
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